P11-4 vs hGHRH(1-40)OH
Head-to-head comparison of P11-4 (Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2)) and hGHRH(1-40)OH (Human growth hormone-releasing factor (1-40) hydroxyl) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | P11-4 | hGHRH(1-40)OH |
|---|---|---|
| Category | Dental & Oral | Growth Hormone |
| Full Name | Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2) | Human growth hormone-releasing factor (1-40) hydroxyl |
| Molecular Weight | 1466 Da | N/A |
| Half-Life | local activity for hours; peptide degraded over time | 5-20 minutes |
| Amino Acids | 11 | 40 |
| Typical Dose | 0.5-5 mg per lesion | 1-2 mcg/kg |
| Route | Topical/Intraoral | Subcutaneous/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 40 | 85 |
| Research Status | Clinical | Clinical Research |
P11-4 Benefits
- ✓enamel remineralization
- ✓early caries arrest
- ✓biomimetic scaffold formation
- ✓minimally invasive repair
hGHRH(1-40)OH Benefits
- ✓GH secretion research
- ✓fragment-activity comparison
- ✓receptor binding studies
- ✓axis physiology modeling
P11-4 Dosing
topical application to cleaned lesion|single-visit in-office application|repeat at follow-up if indicated
hGHRH(1-40)OH Dosing
1-2 mcg/kg SC or IV in acute research settings|single-bolus GH stimulation protocols|repeated low-dose administration in comparative studies
P11-4 Side Effects
- ⚠transient tooth sensitivity
- ⚠local irritation
- ⚠taste disturbance
hGHRH(1-40)OH Side Effects
- ⚠flushing
- ⚠headache
- ⚠lightheadedness
Research Overview
P11-4
P11-4 has been studied for its ability to penetrate initial carious lesions and self-assemble into a fibrillar matrix that nucleates hydroxyapatite. Human and preclinical studies support its role in non-invasive enamel repair.
hGHRH(1-40)OH
Human GHRF(1-40)OH has been studied to understand how truncation of the native hormone changes biological potency and half-life. It is a common research tool for mapping minimal active sequences within the GHRH family.
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