Orexin-A vs Cholecystokinin-8
Head-to-head comparison of Orexin-A (Hypocretin-1 (Orexin-A)) and Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Orexin-A | Cholecystokinin-8 |
|---|---|---|
| Category | Cognitive Enhancement | Endocrine Peptides |
| Full Name | Hypocretin-1 (Orexin-A) | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) |
| Molecular Weight | 3562 Da | 1143.2 Da |
| Half-Life | Minutes to <1 hour | 1-2 min |
| Amino Acids | 33 | DY(SO3H)MGWMDF-NH2 |
| Typical Dose | Research-only; no validated human dose | physiologic low-picomolar-nanomolar range|research-dependent |
| Route | Intracerebroventricular/Intranasal | endogenous secretion|research IV/SC |
| Purity | ≥98% | ≥98% |
| Studies Count | 42 | 97 |
| Research Status | Pre-clinical | Endogenous |
Orexin-A Benefits
- ✓wakefulness
- ✓attention
- ✓memory consolidation
- ✓fatigue resistance
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
Orexin-A Dosing
Research-only i.c.v. microgram/nanomolar studies|intranasal experimental use|no established human protocol
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
Orexin-A Side Effects
- ⚠insomnia
- ⚠headache
- ⚠blood pressure changes
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Research Overview
Orexin-A
Preclinical studies link orexin signaling to arousal, learning, and memory consolidation, making orexin-A a candidate for cognition-related research. It is not an approved cognitive enhancer and remains an experimental peptide.
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
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