Omentin-1 vs TFF3
Head-to-head comparison of Omentin-1 (Omentin-1 (Intelectin-1, ITLN1)) and TFF3 (Trefoil Factor 3 (intestinal trefoil factor)) — benefits, dosing, side effects, research data, and where to buy.
| Property | Omentin-1 | TFF3 |
|---|---|---|
| Category | Diabetes & Metabolic | Gastrointestinal |
| Full Name | Omentin-1 (Intelectin-1, ITLN1) | Trefoil Factor 3 (intestinal trefoil factor) |
| Molecular Weight | ~35 kDa | 6370 Da |
| Half-Life | hours | unknown; likely short in circulation |
| Amino Acids | 313 | 59 |
| Typical Dose | No approved human dose; research use only | research-only; model-dependent microgram to milligram ranges |
| Route | IV|SC | Oral/Intrarectal |
| Purity | ≥98% | ≥98% |
| Studies Count | 82 | 70 |
| Research Status | Pre-clinical | Pre-clinical |
Omentin-1 Benefits
- ✓insulin sensitivity
- ✓glucose uptake
- ✓lipid handling
TFF3 Benefits
- ✓epithelial-restitution
- ✓mucus-support
- ✓wound-healing
- ✓barrier-stability
Omentin-1 Dosing
not established|not established
TFF3 Dosing
preclinical dosing varies widely by model|local or systemic administration|repeated dosing for inflammatory injury studies
Omentin-1 Side Effects
- ⚠unknown
- ⚠immunogenicity risk
TFF3 Side Effects
- ⚠limited human dosing data
- ⚠protein stability issues
- ⚠potential immunogenicity with exogenous use
Research Overview
Omentin-1
Lower omentin-1 levels are often associated with obesity, insulin resistance, and metabolic syndrome. Research continues on its use as a biomarker and as a mechanistic lead for AMPK-linked metabolic interventions.
TFF3
TFF3 is a well-established mucosal repair factor in the literature, especially in the context of intestinal injury and inflammation. Experimental studies support a role in accelerating restitution and protecting the epithelial surface in gut disease models.
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