Neuropeptide S vs GHRP-2
Head-to-head comparison of Neuropeptide S (Neuropeptide S) and GHRP-2 (Growth Hormone Releasing Peptide-2) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Neuropeptide S | GHRP-2 |
|---|---|---|
| Category | Cognitive Enhancement | Performance |
| Full Name | Neuropeptide S | Growth Hormone Releasing Peptide-2 |
| Molecular Weight | 2203 Da | 817.97 Da |
| Half-Life | Minutes to <1 hour | ~25 minutes |
| Amino Acids | 20 | 6 |
| Typical Dose | Research-only; no validated human dose | 100-300 mcg |
| Route | Intracerebroventricular/Intranasal | SC / IV |
| Purity | ≥98% | — |
| Studies Count | 28 | 172 |
| Research Status | Pre-clinical | Approved (Japan) |
Neuropeptide S Benefits
- ✓anxiolysis
- ✓stress resilience
- ✓attention support
- ✓arousal modulation
GHRP-2 Benefits
- ✓Potent GH release (stronger than GHRP-6)
- ✓Less appetite stimulation than GHRP-6
- ✓Improved body composition
- ✓Enhanced deep sleep quality
- ✓Cytoprotective properties
Neuropeptide S Dosing
0.1-1 nmol i.c.v. in animal studies|intranasal research-only exploration|no established human protocol
GHRP-2 Dosing
Standard: 100-300 mcg SC 2-3 times daily|Pre-bed: 100-200 mcg for GH pulse during sleep|Combined: 100 mcg with CJC-1295 for synergy|Cycle: 8-16 weeks, 4 weeks off
Neuropeptide S Side Effects
- ⚠sleep disruption
- ⚠headache
- ⚠jitteriness
GHRP-2 Side Effects
- ⚠Common: Mild appetite increase, water retention, tingling
- ⚠Moderate: Cortisol elevation at higher doses
- ⚠Rare: Prolactin increase, transient dizziness
- ⚠Better tolerated than GHRP-6 overall
Research Overview
Neuropeptide S
Animal studies suggest NPS can reduce anxiety-like behavior while altering wakefulness and alertness through the NPS receptor system. Human cognitive data are very limited, and it has no approved clinical indication.
GHRP-2
GHRP-2 has strong clinical evidence. Approved in Japan for diagnostic use. Multiple human studies confirm reliable GH stimulation with a favorable side effect profile compared to GHRP-6.
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