NGF vs IGF-2
Head-to-head comparison of NGF (Beta-Nerve Growth Factor (human NGF beta)) and IGF-2 (Insulin-Like Growth Factor II) — benefits, dosing, side effects, research data, and where to buy.
| Property | NGF | IGF-2 |
|---|---|---|
| Category | Cognitive Enhancement | Cognitive Enhancement |
| Full Name | Beta-Nerve Growth Factor (human NGF beta) | Insulin-Like Growth Factor II |
| Molecular Weight | 13,600 Da | 7467 Da |
| Half-Life | hours | 6-10 minutes |
| Amino Acids | 118 aa | 67 aa |
| Typical Dose | research-only microgram range | 1-10 µg preclinical range |
| Route | Intranasal | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 3500 | 1200 |
| Research Status | Pre-clinical | Pre-clinical |
NGF Benefits
- ✓neurite outgrowth
- ✓cholinergic support
- ✓nerve repair
- ✓neuroprotection
IGF-2 Benefits
- ✓memory consolidation
- ✓hippocampal plasticity
- ✓synaptic repair
- ✓neuroprotection
NGF Dosing
0.01-1 µg/kg in experimental delivery studies|local CNS or intranasal research delivery|single or repeated low-dose protocols
IGF-2 Dosing
0.1-1 µg ICV in rodents|1-10 µg intrahippocampal in preclinical work|acute post-training protocols
NGF Side Effects
- ⚠pain at injection site
- ⚠hyperalgesia
- ⚠autonomic effects
IGF-2 Side Effects
- ⚠hypoglycemia risk
- ⚠edema
- ⚠insulin-like systemic effects
Research Overview
NGF
NGF is one of the most established growth factors in neurobiology and has been investigated for both central and peripheral neuronal repair. Its strongest cognitive relevance comes from supporting basal forebrain cholinergic neurons and downstream memory circuitry.
IGF-2
IGF-2 has strong preclinical evidence for improving memory formation and supporting synaptic changes tied to learning. It also shows neuroprotective and repair-related effects in models of injury and neurodegeneration.
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