Nafarelin vs Follitropin alfa
Head-to-head comparison of Nafarelin (Nafarelin acetate) and Follitropin alfa (Recombinant Human Follicle-Stimulating Hormone Alfa) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Nafarelin | Follitropin alfa |
|---|---|---|
| Category | Sexual Health | Sexual Health |
| Full Name | Nafarelin acetate | Recombinant Human Follicle-Stimulating Hormone Alfa |
| Molecular Weight | 1321.47 Da | 30,000 Da |
| Half-Life | ~2-4 hours | ~24 hours |
| Amino Acids | 10 | N/A |
| Typical Dose | 200 mcg intranasal twice daily | 75-150 IU per dose |
| Route | Intranasal | Subcutaneous/Intramuscular |
| Purity | ≥98% | ≥98% |
| Studies Count | 220 | 850 |
| Research Status | Clinical | Clinical |
Nafarelin Benefits
- ✓pituitary suppression
- ✓cycle scheduling
- ✓endometriosis-related reproductive care
- ✓controlled hormone modulation
Follitropin alfa Benefits
- ✓supports spermatogenesis
- ✓improves Sertoli cell signaling
- ✓may enhance sperm parameters
- ✓complements LH-driven testosterone support
Nafarelin Dosing
200 mcg intranasal twice daily|0.4 mg/day intranasal|protocol-based suppression cycles
Follitropin alfa Dosing
75-150 IU SC/IM 2-3x weekly|adjust based on FSH and semen analysis|often combined with hCG in men
Nafarelin Side Effects
- ⚠nasal irritation
- ⚠hot flashes
- ⚠headache
Follitropin alfa Side Effects
- ⚠injection-site reactions
- ⚠headache
- ⚠bloating
Research Overview
Nafarelin
Nafarelin has a long history in reproductive medicine, especially for endometriosis and cycle suppression. Studies show it down-regulates the HPG axis after an initial stimulatory flare.
Follitropin alfa
Clinical literature supports follitropin alfa for male infertility, especially when combined with LH activity to optimize testicular output. Its role is strongest in hypogonadotropic hypogonadism and assisted reproduction protocols.
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