Met-enkephalin vs Insulin Glargine
Head-to-head comparison of Met-enkephalin (Tyr-Gly-Gly-Phe-Met) and Insulin Glargine (Insulin glargine (A21Gly,B31Arg,B32Arg human insulin analog)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Met-enkephalin | Insulin Glargine |
|---|---|---|
| Category | Pain Management | Diabetes & Metabolic |
| Full Name | Tyr-Gly-Gly-Phe-Met | Insulin glargine (A21Gly,B31Arg,B32Arg human insulin analog) |
| Molecular Weight | 573.67 Da | 6063.6 Da |
| Half-Life | 1-5 minutes in plasma | About 12-24 hours |
| Amino Acids | 5 | 51 |
| Typical Dose | 0.1-5 ug per animal | 0.1-0.2 U/kg once daily |
| Route | Intrathecal / intracerebroventricular | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 1200 | 13000 |
| Research Status | Pre-clinical | Approved |
Met-enkephalin Benefits
- ✓endogenous opioid signaling
- ✓analgesic reference ligand
- ✓spinal antinociception
- ✓neurochemical pain-pathway probe
Insulin Glargine Benefits
- ✓Once-daily basal coverage
- ✓Smooth action profile
- ✓Lower nocturnal hypoglycemia risk
- ✓Improves fasting glucose control
Met-enkephalin Dosing
Intrathecal 0.1-5 ug per animal|Intracerebroventricular 0.1-2 ug per animal|In vitro 1-100 nM
Insulin Glargine Dosing
Inject SC once daily at the same time each day|Titrate every 3-4 days to fasting glucose targets|Can be combined with prandial insulin
Met-enkephalin Side Effects
- ⚠sedation at higher exposure
- ⚠constipation-like opioid effects
- ⚠rapid enzymatic degradation
Insulin Glargine Side Effects
- ⚠Hypoglycemia
- ⚠Injection-site reactions
- ⚠Weight gain
Research Overview
Met-enkephalin
Met-enkephalin has been extensively used in receptor pharmacology and nociception studies to map mu and delta opioid biology. The main limitation in translational work is very short half-life from peptidase cleavage and poor systemic stability.
Insulin Glargine
Clinical and translational studies support its use as a basal comparator because of prolonged absorption and stable glycemic control. It is heavily used in basal-bolus regimen research and insulin-delivery optimization studies.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.