Lutropin alfa vs Follitropin alfa

Head-to-head comparison of Lutropin alfa (Recombinant Human Luteinizing Hormone Alfa) and Follitropin alfa (Recombinant Human Follicle-Stimulating Hormone Alfa) — benefits, dosing, side effects, research data, and where to buy.

Research Score

PropertyLutropin alfaFollitropin alfa
CategorySexual HealthSexual Health
Full NameRecombinant Human Luteinizing Hormone AlfaRecombinant Human Follicle-Stimulating Hormone Alfa
Molecular Weight30,000 Da30,000 Da
Half-Life~10-12 hours~24 hours
Amino AcidsN/AN/A
Typical Dose75-150 IU per dose75-150 IU per dose
RouteSubcutaneous/IntramuscularSubcutaneous/Intramuscular
Purity≥98%≥98%
Studies Count420850
Research StatusClinicalClinical

Lutropin alfa Benefits

  • stimulates Leydig cells
  • raises endogenous testosterone
  • supports testicular steroidogenesis
  • pairs with FSH for fertility

Follitropin alfa Benefits

  • supports spermatogenesis
  • improves Sertoli cell signaling
  • may enhance sperm parameters
  • complements LH-driven testosterone support

Lutropin alfa Dosing

75-150 IU SC/IM 2-3x weekly|adjust to testosterone response|combine with FSH when spermatogenesis support is needed

Follitropin alfa Dosing

75-150 IU SC/IM 2-3x weekly|adjust based on FSH and semen analysis|often combined with hCG in men

Lutropin alfa Side Effects

  • injection-site reactions
  • headache
  • hormonal swings

Follitropin alfa Side Effects

  • injection-site reactions
  • headache
  • bloating

Research Overview

Lutropin alfa

Lutropin alfa has been evaluated in fertility protocols to restore LH signaling and endogenous testosterone production. It is a direct research/clinical analogue for men with low gonadotropin drive.

Follitropin alfa

Clinical literature supports follitropin alfa for male infertility, especially when combined with LH activity to optimize testicular output. Its role is strongest in hypogonadotropic hypogonadism and assisted reproduction protocols.

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Common Stacking Partners

Lutropin alfa stacks with:

Follitropin alfahCG

Follitropin alfa stacks with:

hCGLutropin alfa
LHtestosteronefertilityclinicalFSHgonadotropin