Ipamorelin vs IGF-1 LR3
Head-to-head comparison of Ipamorelin (Growth Hormone Secretagogue) and IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Ipamorelin | IGF-1 LR3 |
|---|---|---|
| Category | Performance | Performance |
| Full Name | Growth Hormone Secretagogue | Insulin-like Growth Factor-1 Long R3 |
| Molecular Weight | 711.85 Da | 9,117 Da |
| Half-Life | ~2 hours | ~20-30 hours |
| Amino Acids | 5 | 83 |
| Typical Dose | 200-300 mcg | 20-100 mcg |
| Route | SC | IM / SC |
| Purity | — | — |
| Studies Count | 156 | 298 |
| Research Status | Clinical Trials | Pre-clinical |
Ipamorelin Benefits
- ✓Stimulates natural GH release
- ✓Minimal cortisol/prolactin increase
- ✓Improved body composition
- ✓Enhanced recovery and sleep quality
- ✓Anti-aging effects
IGF-1 LR3 Benefits
- ✓Promotes muscle hyperplasia (new muscle cells)
- ✓Extended half-life vs native IGF-1
- ✓Enhanced protein synthesis
- ✓Improved nutrient partitioning
- ✓Anti-catabolic effects
Ipamorelin Dosing
Standard: 200-300 mcg SC 2-3 times daily|Pre-bed: 200 mcg SC 30 min before sleep|Combined: 100-200 mcg with CJC-1295 2-3x daily
IGF-1 LR3 Dosing
Standard: 20-50 mcg IM post-workout|Advanced: 50-100 mcg IM or SC daily|Cycle: 4-6 weeks on, 4 weeks off
Ipamorelin Side Effects
- ⚠Common (Mild): Temporary tingling, water retention, increased appetite
- ⚠Rare: Headache, lightheadedness
- ⚠Very Well Tolerated overall
IGF-1 LR3 Side Effects
- ⚠Common: Hypoglycemia (dose-dependent), joint pain, water retention
- ⚠Moderate: Gut growth concern (high doses), acromegaly-like symptoms
- ⚠Serious: Theoretical cancer risk (prolonged high-dose use)
Research Overview
Ipamorelin
Ipamorelin has moderate clinical evidence. Phase II trials demonstrate selective GH release. Generally regarded as one of the safest GH secretagogues with minimal side effect profile.
IGF-1 LR3
IGF-1 LR3 has extensive in vitro and animal data. Its role in muscle hyperplasia is well-documented. The extended half-life modification provides practical advantages over native IGF-1.
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