Indolicidin vs HNP-1
Head-to-head comparison of Indolicidin (Indolicidin (Bovine Neutrophil Antimicrobial Peptide)) and HNP-1 (Human Neutrophil Peptide 1 (Alpha-Defensin 1)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Indolicidin | HNP-1 |
|---|---|---|
| Category | Immune Support | Immune Support |
| Full Name | Indolicidin (Bovine Neutrophil Antimicrobial Peptide) | Human Neutrophil Peptide 1 (Alpha-Defensin 1) |
| Molecular Weight | 2111 Da | 3443 Da |
| Half-Life | Minutes to hours; protease-sensitive | Minutes to hours; protease-sensitive |
| Amino Acids | 13 | 30 |
| Typical Dose | Research use only; no approved human dose | Research use only; no approved human dose |
| Route | Topical / Research parenteral | Topical / Research parenteral |
| Purity | ≥98% | ≥98% |
| Studies Count | 240 | 610 |
| Research Status | Pre-clinical | Pre-clinical |
Indolicidin Benefits
- ✓broad-spectrum bactericidal activity
- ✓anti-biofilm effects
- ✓membrane disruption
- ✓innate immune support
HNP-1 Benefits
- ✓neutrophil-derived antimicrobial defense
- ✓broad pathogen killing
- ✓immune cell signaling
- ✓mucosal protection
Indolicidin Dosing
0.1–10 µM in vitro|1–10 mg/kg in animal models|No established human dose
HNP-1 Dosing
0.1–10 µM in vitro|1–5 mg/kg in animal models|No established human dose
Indolicidin Side Effects
- ⚠cell membrane toxicity at high doses
- ⚠rapid degradation in vivo
- ⚠limited systemic tolerability
HNP-1 Side Effects
- ⚠membrane toxicity at high concentrations
- ⚠short in vivo stability
- ⚠potential inflammation amplification
Research Overview
Indolicidin
Indolicidin has been extensively studied as a prototype antimicrobial peptide with activity against bacteria, fungi, and some viruses. Research has also explored its use in anti-biofilm strategies and as a template for next-generation synthetic antimicrobial peptides.
HNP-1
HNP-1 has been studied as a key component of neutrophil-mediated host defense against bacteria, fungi, and some enveloped viruses. Literature also reports immunomodulatory effects, including impacts on chemotaxis, cytokine release, and barrier defense.
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