IGF-1 DES vs Secretin
Head-to-head comparison of IGF-1 DES (Des(1-3) Insulin-like Growth Factor 1) and Secretin (Human Secretin) — benefits, dosing, side effects, research data, and where to buy.
| Property | IGF-1 DES | Secretin |
|---|---|---|
| Category | Growth Hormone | Gastrointestinal |
| Full Name | Des(1-3) Insulin-like Growth Factor 1 | Human Secretin |
| Molecular Weight | 7365 Da | 3055.4 Da |
| Half-Life | ~20-30 minutes | 5-7 minutes |
| Amino Acids | 67 | 27 |
| Typical Dose | — | 0.2 mcg/kg IV |
| Route | — | Intravenous |
| Purity | >98% | ≥98% |
| Studies Count | 65 | 800 |
| Research Status | Active Research | Clinical |
IGF-1 DES Benefits
- ✓Highly potent localized muscle growth, enhanced protein synthesis, satellite cell proliferation, does not bind to IGFBPs, rapid onset
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
IGF-1 DES Dosing
50-150 mcg per injection site bilaterally post-workout. 4-6 week cycles due to potency. Multiple daily injections in research.
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
IGF-1 DES Side Effects
- ⚠Hypoglycemia (dose-dependent), localized swelling, shorter duration limits systemic exposure compared to IGF-1 LR3.
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
Research Overview
IGF-1 DES
Missing first three amino acids (Gly-Pro-Glu) eliminates IGFBP binding, resulting in 100% bioavailable IGF-1R stimulation. Activates PI3K/Akt/mTOR for protein synthesis and satellite cell proliferation.
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
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