IGF-1 DES vs GHRP-6
Head-to-head comparison of IGF-1 DES (Des(1-3) Insulin-like Growth Factor 1) and GHRP-6 (Growth Hormone Releasing Peptide-6) — benefits, dosing, side effects, research data, and where to buy.
| Property | IGF-1 DES | GHRP-6 |
|---|---|---|
| Category | Growth Hormone | Performance |
| Full Name | Des(1-3) Insulin-like Growth Factor 1 | Growth Hormone Releasing Peptide-6 |
| Molecular Weight | 7365 Da | 873.01 Da |
| Half-Life | ~20-30 minutes | ~15-60 minutes |
| Amino Acids | 67 | 6 |
| Typical Dose | — | 100-300 mcg |
| Route | — | SC / IV |
| Purity | >98% | — |
| Studies Count | 65 | 186 |
| Research Status | Active Research | Clinical Trials |
IGF-1 DES Benefits
- ✓Highly potent localized muscle growth, enhanced protein synthesis, satellite cell proliferation, does not bind to IGFBPs, rapid onset
GHRP-6 Benefits
- ✓Potent GH release stimulation
- ✓Muscle growth and strength
- ✓Appetite stimulation (ghrelin pathway)
- ✓Improved body composition
- ✓Enhanced recovery from training
IGF-1 DES Dosing
50-150 mcg per injection site bilaterally post-workout. 4-6 week cycles due to potency. Multiple daily injections in research.
GHRP-6 Dosing
Standard: 100-300 mcg SC 2-3 times daily|Pre-workout: 100 mcg 30 min before training|Pre-bed: 100-200 mcg for overnight GH pulse
IGF-1 DES Side Effects
- ⚠Hypoglycemia (dose-dependent), localized swelling, shorter duration limits systemic exposure compared to IGF-1 LR3.
GHRP-6 Side Effects
- ⚠Common: Increased appetite (significant), water retention, tingling
- ⚠Moderate: Cortisol elevation (dose-dependent), lethargy
- ⚠Rare: Elevated prolactin at high doses
Research Overview
IGF-1 DES
Missing first three amino acids (Gly-Pro-Glu) eliminates IGFBP binding, resulting in 100% bioavailable IGF-1R stimulation. Activates PI3K/Akt/mTOR for protein synthesis and satellite cell proliferation.
GHRP-6
GHRP-6 has solid pre-clinical and clinical evidence for GH stimulation. Well-characterized pharmacology. More appetite stimulation than Ipamorelin due to ghrelin receptor activation.
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