IGF-1 DES vs CJC-1295
Head-to-head comparison of IGF-1 DES (Des(1-3) Insulin-like Growth Factor 1) and CJC-1295 (Growth Hormone Releasing Hormone Analog) — benefits, dosing, side effects, research data, and where to buy.
| Property | IGF-1 DES | CJC-1295 |
|---|---|---|
| Category | Growth Hormone | Performance |
| Full Name | Des(1-3) Insulin-like Growth Factor 1 | Growth Hormone Releasing Hormone Analog |
| Molecular Weight | 7365 Da | 3,367.97 Da |
| Half-Life | ~20-30 minutes | ~6-8 days (DAC) |
| Amino Acids | 67 | 30 |
| Typical Dose | — | 1-2 mg/week |
| Route | — | SC |
| Purity | >98% | — |
| Studies Count | 65 | 167 |
| Research Status | Active Research | Clinical Trials |
IGF-1 DES Benefits
- ✓Highly potent localized muscle growth, enhanced protein synthesis, satellite cell proliferation, does not bind to IGFBPs, rapid onset
CJC-1295 Benefits
- ✓Sustained GH release over days
- ✓Improved body composition
- ✓Enhanced deep sleep quality
- ✓Accelerated recovery from training
- ✓Increased protein synthesis
IGF-1 DES Dosing
50-150 mcg per injection site bilaterally post-workout. 4-6 week cycles due to potency. Multiple daily injections in research.
CJC-1295 Dosing
Without DAC: 100-200 mcg SC 2-3 times daily|With DAC: 1-2 mg SC once or twice weekly|Combined with Ipamorelin: 100 mcg each, 2-3x daily
IGF-1 DES Side Effects
- ⚠Hypoglycemia (dose-dependent), localized swelling, shorter duration limits systemic exposure compared to IGF-1 LR3.
CJC-1295 Side Effects
- ⚠Common (Mild): Water retention, tingling/numbness, flushing
- ⚠Moderate: Joint stiffness, carpal tunnel-like symptoms
- ⚠Rare: Elevated blood sugar (transient)
Research Overview
IGF-1 DES
Missing first three amino acids (Gly-Pro-Glu) eliminates IGFBP binding, resulting in 100% bioavailable IGF-1R stimulation. Activates PI3K/Akt/mTOR for protein synthesis and satellite cell proliferation.
CJC-1295
CJC-1295 has good pre-clinical and early clinical data. The DAC variant shows sustained GH elevation for days. Often combined with GHRPs for synergistic GH release.
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