Epoetin Alfa vs FS315
Head-to-head comparison of Epoetin Alfa (Recombinant human erythropoietin alfa) and FS315 (Follistatin-315 (FS315)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Epoetin Alfa | FS315 |
|---|---|---|
| Category | Muscle & Performance | Muscle & Performance |
| Full Name | Recombinant human erythropoietin alfa | Follistatin-315 (FS315) |
| Molecular Weight | ≈30,400 Da | ~40 kDa |
| Half-Life | ~4-13 h IV; ~20-30 h SC | N/A; depends on construct/delivery |
| Amino Acids | 165 | 315 |
| Typical Dose | 50-100 IU/kg SC 3x weekly or 40,000 IU SC weekly | Research-only; no standardized human dose |
| Route | Subcutaneous/IV | Intramuscular / research expression systems |
| Purity | ≥98% | ≥98% |
| Studies Count | 320 | 95 |
| Research Status | Clinical | Pre-clinical |
Epoetin Alfa Benefits
- ✓raises hemoglobin
- ✓increases oxygen-carrying capacity
- ✓may increase VO2 max
- ✓improves time-to-exhaustion
FS315 Benefits
- ✓activin neutralization
- ✓muscle growth signaling
- ✓anti-catabolic support
- ✓tissue repair modulation
Epoetin Alfa Dosing
50-100 IU/kg subcutaneous 3x weekly|40,000 IU subcutaneous weekly|Titrate to hemoglobin target under medical supervision
FS315 Dosing
Research-only recombinant/protein-expression studies|no standardized clinical dose|route varies by platform
Epoetin Alfa Side Effects
- ⚠hypertension
- ⚠thrombosis
- ⚠polycythemia
FS315 Side Effects
- ⚠off-target endocrine effects
- ⚠immune response risk
- ⚠fluid balance changes
Research Overview
Epoetin Alfa
Human studies in anemia and performance-related settings show that increasing red-cell mass can improve aerobic capacity and endurance. It remains heavily regulated because excessive erythropoiesis raises thrombotic and cardiovascular risk.
FS315
Follistatin-315 is a key reference isoform in studies of muscle anabolism and reproductive/endocrine biology. In muscle research, it is relevant because it suppresses activin and can indirectly blunt myostatin pathway output.
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