EGF vs P-15
Head-to-head comparison of EGF (Human Epidermal Growth Factor) and P-15 (Synthetic Collagen Type I Cell-Binding Peptide (P-15)) — benefits, dosing, side effects, research data, and where to buy.
| Property | EGF | P-15 |
|---|---|---|
| Category | Recovery & Healing | Recovery & Healing |
| Full Name | Human Epidermal Growth Factor | Synthetic Collagen Type I Cell-Binding Peptide (P-15) |
| Molecular Weight | 6.0 kDa | 1500 Da |
| Half-Life | minutes | N/A |
| Amino Acids | 53 | 15 |
| Typical Dose | 0.04–0.1 mg/cm²/day | device-dependent local loading |
| Route | Topical | Local/Implant |
| Purity | ≥98% | ≥98% |
| Studies Count | 650 | 150 |
| Research Status | Clinical | Clinical |
EGF Benefits
- ✓re-epithelialization
- ✓fibroblast activation
- ✓angiogenesis support
- ✓faster ulcer closure
P-15 Benefits
- ✓improves osteoblast attachment
- ✓supports scaffold osteointegration
- ✓enhances bone fill
- ✓may aid periodontal regeneration
EGF Dosing
Topical daily|0.04–0.1 mg/cm²|short courses until granulation/closure
P-15 Dosing
embedded in scaffold or graft material|local application|single procedural exposure
EGF Side Effects
- ⚠local irritation
- ⚠erythema
- ⚠theoretical hyperproliferation
- ⚠pain at site
P-15 Side Effects
- ⚠local irritation
- ⚠inflammation
- ⚠hypersensitivity
Research Overview
EGF
Human and animal studies show EGF can accelerate epithelial migration and wound closure, especially in burns, ulcers, and mucosal injury. Its best evidence is for topical or local delivery because systemic exposure is brief and the effect is highly localized.
P-15
P-15 is a real literature-backed peptide used to improve biomaterial performance in bone repair settings. Most of the evidence is device- or scaffold-based rather than as a free systemic peptide.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.