EGF vs FGF2
Head-to-head comparison of EGF (Human Epidermal Growth Factor) and FGF2 (Recombinant Human Fibroblast Growth Factor 2) — benefits, dosing, side effects, research data, and where to buy.
| Property | EGF | FGF2 |
|---|---|---|
| Category | Recovery & Healing | Recovery & Healing |
| Full Name | Human Epidermal Growth Factor | Recombinant Human Fibroblast Growth Factor 2 |
| Molecular Weight | 6.0 kDa | 17.2 kDa |
| Half-Life | minutes | minutes to <1 hour local |
| Amino Acids | 53 | 155 |
| Typical Dose | 0.04–0.1 mg/cm²/day | 1–10 µg/cm²/day |
| Route | Topical | Topical |
| Purity | ≥98% | ≥98% |
| Studies Count | 650 | 1200 |
| Research Status | Clinical | Clinical |
EGF Benefits
- ✓re-epithelialization
- ✓fibroblast activation
- ✓angiogenesis support
- ✓faster ulcer closure
FGF2 Benefits
- ✓angiogenesis
- ✓fibroblast proliferation
- ✓granulation tissue formation
- ✓accelerated re-epithelialization
EGF Dosing
Topical daily|0.04–0.1 mg/cm²|short courses until granulation/closure
FGF2 Dosing
Topical spray/gel daily|intralesional microdoses in studies|short cycles during active repair
EGF Side Effects
- ⚠local irritation
- ⚠erythema
- ⚠theoretical hyperproliferation
- ⚠pain at site
FGF2 Side Effects
- ⚠local swelling
- ⚠pain
- ⚠fibroblast overgrowth/scarring
- ⚠theoretical malignancy concern
Research Overview
EGF
Human and animal studies show EGF can accelerate epithelial migration and wound closure, especially in burns, ulcers, and mucosal injury. Its best evidence is for topical or local delivery because systemic exposure is brief and the effect is highly localized.
FGF2
FGF2 has extensive preclinical and clinical literature for skin ulcers, burns, and postsurgical repair, largely through angiogenic and mesenchymal-cell signaling. It remains one of the most studied repair factors for improving tissue perfusion and remodeling.
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