Cholecystokinin-8 vs Exendin-4
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and Exendin-4 (Exendin-4 (synthetic exenatide)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | Exendin-4 |
|---|---|---|
| Category | Endocrine Peptides | Diabetes & Metabolic |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Exendin-4 (synthetic exenatide) |
| Molecular Weight | 1143.2 Da | 4186 Da |
| Half-Life | 1-2 min | 2.4 hours |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 39 |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | 5-10 mcg twice daily |
| Route | endogenous secretion|research IV/SC | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 1800 |
| Research Status | Endogenous | Clinical |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
Exendin-4 Benefits
- ✓beta-cell survival
- ✓glucose-stimulated insulin secretion
- ✓reduced glucolipotoxicity
- ✓lowered HbA1c in clinical use
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
Exendin-4 Dosing
5 mcg SC twice daily for 4 weeks|increase to 10 mcg SC twice daily if tolerated|research: 0.1-1 µM in vitro or 1-10 µg/kg in animals
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Exendin-4 Side Effects
- ⚠nausea
- ⚠vomiting
- ⚠injection-site reactions
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
Exendin-4
Exendin-4 helped establish GLP-1 receptor biology in diabetes and remains a classic beta-cell protective peptide. Preclinical studies show reduced beta-cell apoptosis, improved insulin content, and better islet function under metabolic stress.
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