Cholecystokinin-8 vs BDNF
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and BDNF (Brain-Derived Neurotrophic Factor (mature BDNF)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | BDNF |
|---|---|---|
| Category | Endocrine Peptides | Cognitive Enhancement |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Brain-Derived Neurotrophic Factor (mature BDNF) |
| Molecular Weight | 1143.2 Da | 13,700 Da |
| Half-Life | 1-2 min | minutes to hours |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 119 aa |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | research-only microgram range |
| Route | endogenous secretion|research IV/SC | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 8000 |
| Research Status | Endogenous | Pre-clinical |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
BDNF Benefits
- ✓neurogenesis
- ✓synaptogenesis
- ✓LTP support
- ✓neuronal survival
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
BDNF Dosing
0.1-1 µg local or intranasal research delivery|viral or protein infusion models|acute or repeated plasticity protocols
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
BDNF Side Effects
- ⚠off-target neuroexcitation
- ⚠headache-like effects
- ⚠unknown systemic protein effects
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
BDNF
BDNF is repeatedly associated with learning, long-term potentiation, and recovery from neurologic injury in preclinical literature. Direct protein delivery is difficult, so most studies focus on pathways that raise endogenous BDNF or on localized experimental administration.
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