C-peptide vs Oxyntomodulin
Head-to-head comparison of C-peptide (Connecting peptide (C-peptide)) and Oxyntomodulin (Endogenous glucagon-like peptide 1 and glucagon co-agonist peptide) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | C-peptide | Oxyntomodulin |
|---|---|---|
| Category | Pain Management | Weight Management |
| Full Name | Connecting peptide (C-peptide) | Endogenous glucagon-like peptide 1 and glucagon co-agonist peptide |
| Molecular Weight | 3020.3 Da | ~4,200 Da |
| Half-Life | ~20-30 min | 12-15 minutes |
| Amino Acids | 31 | 37 |
| Typical Dose | no approved analgesic dose|research-only | Research doses vary; commonly 100-300 mcg in small human studies |
| Route | IV|subQ | Subcutaneous/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 46 | 80 |
| Research Status | Pre-clinical | Clinical |
C-peptide Benefits
- ✓diabetic neuropathy research
- ✓nerve function support
- ✓possible analgesic effect
Oxyntomodulin Benefits
- ✓reduces appetite
- ✓increases satiety
- ✓supports weight loss
- ✓improves postprandial metabolic signaling
C-peptide Dosing
0.5-1.0 mg/day in research|route varies by protocol
Oxyntomodulin Dosing
Research-only dosing|Subcutaneous or IV administration in trials|Pair with calorie restriction and monitoring
C-peptide Side Effects
- ⚠injection-site reactions
- ⚠unknown long-term safety
Oxyntomodulin Side Effects
- ⚠nausea
- ⚠GI discomfort
- ⚠decreased appetite beyond target
Research Overview
C-peptide
C-peptide is not an approved analgesic, but multiple studies have examined its effects on peripheral nerve blood flow and neuropathy outcomes. The strongest relevance is in diabetic neuropathic pain rather than migraine.
Oxyntomodulin
Human studies showed acute reductions in food intake and modest weight loss, helping establish the GLP-1 and glucagon co-agonism concept. It remains a foundational peptide for obesity and satiety research.
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