C-peptide vs Neuropeptide S
Head-to-head comparison of C-peptide (Connecting peptide (C-peptide)) and Neuropeptide S (Neuropeptide S) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | C-peptide | Neuropeptide S |
|---|---|---|
| Category | Pain Management | Cognitive Enhancement |
| Full Name | Connecting peptide (C-peptide) | Neuropeptide S |
| Molecular Weight | 3020.3 Da | 2203 Da |
| Half-Life | ~20-30 min | Minutes to <1 hour |
| Amino Acids | 31 | 20 |
| Typical Dose | no approved analgesic dose|research-only | Research-only; no validated human dose |
| Route | IV|subQ | Intracerebroventricular/Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 46 | 28 |
| Research Status | Pre-clinical | Pre-clinical |
C-peptide Benefits
- ✓diabetic neuropathy research
- ✓nerve function support
- ✓possible analgesic effect
Neuropeptide S Benefits
- ✓anxiolysis
- ✓stress resilience
- ✓attention support
- ✓arousal modulation
C-peptide Dosing
0.5-1.0 mg/day in research|route varies by protocol
Neuropeptide S Dosing
0.1-1 nmol i.c.v. in animal studies|intranasal research-only exploration|no established human protocol
C-peptide Side Effects
- ⚠injection-site reactions
- ⚠unknown long-term safety
Neuropeptide S Side Effects
- ⚠sleep disruption
- ⚠headache
- ⚠jitteriness
Research Overview
C-peptide
C-peptide is not an approved analgesic, but multiple studies have examined its effects on peripheral nerve blood flow and neuropathy outcomes. The strongest relevance is in diabetic neuropathic pain rather than migraine.
Neuropeptide S
Animal studies suggest NPS can reduce anxiety-like behavior while altering wakefulness and alertness through the NPS receptor system. Human cognitive data are very limited, and it has no approved clinical indication.
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