C-peptide vs NGF
Head-to-head comparison of C-peptide (Connecting peptide (C-peptide)) and NGF (Beta-Nerve Growth Factor (human NGF beta)) — benefits, dosing, side effects, research data, and where to buy.
| Property | C-peptide | NGF |
|---|---|---|
| Category | Pain Management | Cognitive Enhancement |
| Full Name | Connecting peptide (C-peptide) | Beta-Nerve Growth Factor (human NGF beta) |
| Molecular Weight | 3020.3 Da | 13,600 Da |
| Half-Life | ~20-30 min | hours |
| Amino Acids | 31 | 118 aa |
| Typical Dose | no approved analgesic dose|research-only | research-only microgram range |
| Route | IV|subQ | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 46 | 3500 |
| Research Status | Pre-clinical | Pre-clinical |
C-peptide Benefits
- ✓diabetic neuropathy research
- ✓nerve function support
- ✓possible analgesic effect
NGF Benefits
- ✓neurite outgrowth
- ✓cholinergic support
- ✓nerve repair
- ✓neuroprotection
C-peptide Dosing
0.5-1.0 mg/day in research|route varies by protocol
NGF Dosing
0.01-1 µg/kg in experimental delivery studies|local CNS or intranasal research delivery|single or repeated low-dose protocols
C-peptide Side Effects
- ⚠injection-site reactions
- ⚠unknown long-term safety
NGF Side Effects
- ⚠pain at injection site
- ⚠hyperalgesia
- ⚠autonomic effects
Research Overview
C-peptide
C-peptide is not an approved analgesic, but multiple studies have examined its effects on peripheral nerve blood flow and neuropathy outcomes. The strongest relevance is in diabetic neuropathic pain rather than migraine.
NGF
NGF is one of the most established growth factors in neurobiology and has been investigated for both central and peripheral neuronal repair. Its strongest cognitive relevance comes from supporting basal forebrain cholinergic neurons and downstream memory circuitry.
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