C-peptide vs GHRP-2
Head-to-head comparison of C-peptide (Connecting peptide (C-peptide)) and GHRP-2 (Growth Hormone Releasing Peptide-2) — benefits, dosing, side effects, research data, and where to buy.
| Property | C-peptide | GHRP-2 |
|---|---|---|
| Category | Pain Management | Performance |
| Full Name | Connecting peptide (C-peptide) | Growth Hormone Releasing Peptide-2 |
| Molecular Weight | 3020.3 Da | 817.97 Da |
| Half-Life | ~20-30 min | ~25 minutes |
| Amino Acids | 31 | 6 |
| Typical Dose | no approved analgesic dose|research-only | 100-300 mcg |
| Route | IV|subQ | SC / IV |
| Purity | ≥98% | — |
| Studies Count | 46 | 172 |
| Research Status | Pre-clinical | Approved (Japan) |
C-peptide Benefits
- ✓diabetic neuropathy research
- ✓nerve function support
- ✓possible analgesic effect
GHRP-2 Benefits
- ✓Potent GH release (stronger than GHRP-6)
- ✓Less appetite stimulation than GHRP-6
- ✓Improved body composition
- ✓Enhanced deep sleep quality
- ✓Cytoprotective properties
C-peptide Dosing
0.5-1.0 mg/day in research|route varies by protocol
GHRP-2 Dosing
Standard: 100-300 mcg SC 2-3 times daily|Pre-bed: 100-200 mcg for GH pulse during sleep|Combined: 100 mcg with CJC-1295 for synergy|Cycle: 8-16 weeks, 4 weeks off
C-peptide Side Effects
- ⚠injection-site reactions
- ⚠unknown long-term safety
GHRP-2 Side Effects
- ⚠Common: Mild appetite increase, water retention, tingling
- ⚠Moderate: Cortisol elevation at higher doses
- ⚠Rare: Prolactin increase, transient dizziness
- ⚠Better tolerated than GHRP-6 overall
Research Overview
C-peptide
C-peptide is not an approved analgesic, but multiple studies have examined its effects on peripheral nerve blood flow and neuropathy outcomes. The strongest relevance is in diabetic neuropathic pain rather than migraine.
GHRP-2
GHRP-2 has strong clinical evidence. Approved in Japan for diagnostic use. Multiple human studies confirm reliable GH stimulation with a favorable side effect profile compared to GHRP-6.
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