C-peptide vs GHRP-6
Head-to-head comparison of C-peptide (Connecting peptide (C-peptide)) and GHRP-6 (Growth Hormone Releasing Peptide-6) — benefits, dosing, side effects, research data, and where to buy.
| Property | C-peptide | GHRP-6 |
|---|---|---|
| Category | Pain Management | Performance |
| Full Name | Connecting peptide (C-peptide) | Growth Hormone Releasing Peptide-6 |
| Molecular Weight | 3020.3 Da | 873.01 Da |
| Half-Life | ~20-30 min | ~15-60 minutes |
| Amino Acids | 31 | 6 |
| Typical Dose | no approved analgesic dose|research-only | 100-300 mcg |
| Route | IV|subQ | SC / IV |
| Purity | ≥98% | — |
| Studies Count | 46 | 186 |
| Research Status | Pre-clinical | Clinical Trials |
C-peptide Benefits
- ✓diabetic neuropathy research
- ✓nerve function support
- ✓possible analgesic effect
GHRP-6 Benefits
- ✓Potent GH release stimulation
- ✓Muscle growth and strength
- ✓Appetite stimulation (ghrelin pathway)
- ✓Improved body composition
- ✓Enhanced recovery from training
C-peptide Dosing
0.5-1.0 mg/day in research|route varies by protocol
GHRP-6 Dosing
Standard: 100-300 mcg SC 2-3 times daily|Pre-workout: 100 mcg 30 min before training|Pre-bed: 100-200 mcg for overnight GH pulse
C-peptide Side Effects
- ⚠injection-site reactions
- ⚠unknown long-term safety
GHRP-6 Side Effects
- ⚠Common: Increased appetite (significant), water retention, tingling
- ⚠Moderate: Cortisol elevation (dose-dependent), lethargy
- ⚠Rare: Elevated prolactin at high doses
Research Overview
C-peptide
C-peptide is not an approved analgesic, but multiple studies have examined its effects on peripheral nerve blood flow and neuropathy outcomes. The strongest relevance is in diabetic neuropathic pain rather than migraine.
GHRP-6
GHRP-6 has solid pre-clinical and clinical evidence for GH stimulation. Well-characterized pharmacology. More appetite stimulation than Ipamorelin due to ghrelin receptor activation.
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