Bremelanotide vs Oxyntomodulin
Head-to-head comparison of Bremelanotide (Bremelanotide (PT-141), cyclic melanocortin receptor agonist) and Oxyntomodulin (Endogenous glucagon-like peptide 1 and glucagon co-agonist peptide) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Bremelanotide | Oxyntomodulin |
|---|---|---|
| Category | Sexual Health | Weight Management |
| Full Name | Bremelanotide (PT-141), cyclic melanocortin receptor agonist | Endogenous glucagon-like peptide 1 and glucagon co-agonist peptide |
| Molecular Weight | 1025.2 Da | ~4,200 Da |
| Half-Life | about 2.7 h | 12-15 minutes |
| Amino Acids | 7 | 37 |
| Typical Dose | 1.75 mg | Research doses vary; commonly 100-300 mcg in small human studies |
| Route | Subcutaneous | Subcutaneous/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 200 | 80 |
| Research Status | Clinical | Clinical |
Bremelanotide Benefits
- ✓increases sexual desire
- ✓supports arousal
- ✓may improve erectile response
- ✓on-demand use
Oxyntomodulin Benefits
- ✓reduces appetite
- ✓increases satiety
- ✓supports weight loss
- ✓improves postprandial metabolic signaling
Bremelanotide Dosing
1.75 mg subcutaneous PRN|administer about 45 minutes before activity|max 1 dose per 24 hours
Oxyntomodulin Dosing
Research-only dosing|Subcutaneous or IV administration in trials|Pair with calorie restriction and monitoring
Bremelanotide Side Effects
- ⚠nausea
- ⚠flushing
- ⚠headache
- ⚠transient blood pressure increase
Oxyntomodulin Side Effects
- ⚠nausea
- ⚠GI discomfort
- ⚠decreased appetite beyond target
Research Overview
Bremelanotide
Human studies and approval data support meaningful effects on sexual desire in women, with a central mechanism involving melanocortin signaling. It is one of the most clinically relevant peptides in this category and is commonly used as the reference compound for PT-141-type research.
Oxyntomodulin
Human studies showed acute reductions in food intake and modest weight loss, helping establish the GLP-1 and glucagon co-agonism concept. It remains a foundational peptide for obesity and satiety research.
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