Arenicin-1 vs Macimorelin

Head-to-head comparison of Arenicin-1 (Arenicin-1) and Macimorelin (Macimorelin acetate (AEZS-130)) — benefits, dosing, side effects, research data, and where to buy.

Research Score

PropertyArenicin-1Macimorelin
CategoryMarine-DerivedGrowth Hormone
Full NameArenicin-1Macimorelin acetate (AEZS-130)
Molecular Weight2079 DaN/A
Half-Lifen/aabout 4-6 hours
Amino Acids21N/A
Typical Dosen/a0.5 mg/kg single oral dose
RoutepreclinicalOral
Purity≥98%≥98%
Studies Count76120
Research StatusPre-clinicalClinical

Arenicin-1 Benefits

  • antimicrobial
  • anti-biofilm
  • membrane-active

Macimorelin Benefits

  • diagnostic GH stimulation
  • single oral dose
  • rapid measurable GH response
  • high clinical utility

Arenicin-1 Dosing

bacterial infection|biofilm disruption

Macimorelin Dosing

0.5 mg/kg orally as a single dose|fasted testing conditions|serial GH sampling after administration

Arenicin-1 Side Effects

  • Arenicola marina

Macimorelin Side Effects

  • dysgeusia or taste disturbance
  • nausea
  • headache

Research Overview

Arenicin-1

Marine annelid peptide with strong preclinical antibacterial activity and a stable structural motif that is useful for peptide engineering.

Macimorelin

Macimorelin has been validated in clinical testing as an oral alternative to injectable GH stimulation tests. Its short-term use makes it a useful translational tool for evaluating pituitary GH reserve.

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Common Stacking Partners

Arenicin-1 stacks with:

Arenicola marinabeta-hairpinantibiotic

Macimorelin stacks with:

Pituitary testingEndocrine workup
marine-derivedbioactiveantimicrobial peptidebiofilmdiagnosticghrelin-mimeticgh-stimulation-test