5-Amino-1MQ vs Setmelanotide
Head-to-head comparison of 5-Amino-1MQ (5-Amino-1-methylquinolinium) and Setmelanotide (Setmelanotide Acetate) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | 5-Amino-1MQ | Setmelanotide |
|---|---|---|
| Category | Weight Management | Weight Management |
| Full Name | 5-Amino-1-methylquinolinium | Setmelanotide Acetate |
| Molecular Weight | 178.23 g/mol | N/A |
| Half-Life | ~6 hours | Approximately 11-16 hours |
| Amino Acids | Small molecule | N/A |
| Typical Dose | — | 1-3 mg daily |
| Route | — | Subcutaneous |
| Purity | >98% | ≥98% |
| Studies Count | 28 | 80 |
| Research Status | Active Research | Clinical |
5-Amino-1MQ Benefits
- ✓Reduces body fat without appetite changes, lowers cholesterol, increases NAD+ levels, improves metabolic efficiency, supports cellular energy production
Setmelanotide Benefits
- ✓reduced hyperphagia
- ✓body-weight reduction
- ✓MC4R pathway activation
- ✓improved satiety signaling
5-Amino-1MQ Dosing
Research doses: 50-150 mg orally daily. Often cycled 8-12 weeks on, 4 weeks off. Best taken in the morning.
Setmelanotide Dosing
1 mg SC daily|titrate weekly to 2-3 mg/day|follow study or label-based escalation
5-Amino-1MQ Side Effects
- ⚠Generally well-tolerated in preclinical models. Potential mild GI discomfort and headache. Long-term human safety data is limited.
Setmelanotide Side Effects
- ⚠hyperpigmentation
- ⚠nausea
- ⚠injection-site reactions
- ⚠fatigue
Research Overview
5-Amino-1MQ
Studies in diet-induced obese mice showed significant reductions in body weight, white adipose tissue mass, and cholesterol levels without changes in food intake. Works by inhibiting NNMT enzyme to increase NAD+ and activate sirtuins.
Setmelanotide
Setmelanotide has shown clinically meaningful reductions in hunger and weight in POMC, PCSK1, and LEPR-related obesity. It is one of the most important mechanistic peptides for rare-disease obesity research.
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