5-Amino-1MQ vs Orexin-A
Head-to-head comparison of 5-Amino-1MQ (5-Amino-1-methylquinolinium) and Orexin-A (Hypocretin-1 (Orexin-A)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | 5-Amino-1MQ | Orexin-A |
|---|---|---|
| Category | Weight Management | Cognitive Enhancement |
| Full Name | 5-Amino-1-methylquinolinium | Hypocretin-1 (Orexin-A) |
| Molecular Weight | 178.23 g/mol | 3562 Da |
| Half-Life | ~6 hours | Minutes to <1 hour |
| Amino Acids | Small molecule | 33 |
| Typical Dose | — | Research-only; no validated human dose |
| Route | — | Intracerebroventricular/Intranasal |
| Purity | >98% | ≥98% |
| Studies Count | 28 | 42 |
| Research Status | Active Research | Pre-clinical |
5-Amino-1MQ Benefits
- ✓Reduces body fat without appetite changes, lowers cholesterol, increases NAD+ levels, improves metabolic efficiency, supports cellular energy production
Orexin-A Benefits
- ✓wakefulness
- ✓attention
- ✓memory consolidation
- ✓fatigue resistance
5-Amino-1MQ Dosing
Research doses: 50-150 mg orally daily. Often cycled 8-12 weeks on, 4 weeks off. Best taken in the morning.
Orexin-A Dosing
Research-only i.c.v. microgram/nanomolar studies|intranasal experimental use|no established human protocol
5-Amino-1MQ Side Effects
- ⚠Generally well-tolerated in preclinical models. Potential mild GI discomfort and headache. Long-term human safety data is limited.
Orexin-A Side Effects
- ⚠insomnia
- ⚠headache
- ⚠blood pressure changes
Research Overview
5-Amino-1MQ
Studies in diet-induced obese mice showed significant reductions in body weight, white adipose tissue mass, and cholesterol levels without changes in food intake. Works by inhibiting NNMT enzyme to increase NAD+ and activate sirtuins.
Orexin-A
Preclinical studies link orexin signaling to arousal, learning, and memory consolidation, making orexin-A a candidate for cognition-related research. It is not an approved cognitive enhancer and remains an experimental peptide.
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