5-Amino-1MQ vs Neuropeptide S
Head-to-head comparison of 5-Amino-1MQ (5-Amino-1-methylquinolinium) and Neuropeptide S (Neuropeptide S) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | 5-Amino-1MQ | Neuropeptide S |
|---|---|---|
| Category | Weight Management | Cognitive Enhancement |
| Full Name | 5-Amino-1-methylquinolinium | Neuropeptide S |
| Molecular Weight | 178.23 g/mol | 2203 Da |
| Half-Life | ~6 hours | Minutes to <1 hour |
| Amino Acids | Small molecule | 20 |
| Typical Dose | — | Research-only; no validated human dose |
| Route | — | Intracerebroventricular/Intranasal |
| Purity | >98% | ≥98% |
| Studies Count | 28 | 28 |
| Research Status | Active Research | Pre-clinical |
5-Amino-1MQ Benefits
- ✓Reduces body fat without appetite changes, lowers cholesterol, increases NAD+ levels, improves metabolic efficiency, supports cellular energy production
Neuropeptide S Benefits
- ✓anxiolysis
- ✓stress resilience
- ✓attention support
- ✓arousal modulation
5-Amino-1MQ Dosing
Research doses: 50-150 mg orally daily. Often cycled 8-12 weeks on, 4 weeks off. Best taken in the morning.
Neuropeptide S Dosing
0.1-1 nmol i.c.v. in animal studies|intranasal research-only exploration|no established human protocol
5-Amino-1MQ Side Effects
- ⚠Generally well-tolerated in preclinical models. Potential mild GI discomfort and headache. Long-term human safety data is limited.
Neuropeptide S Side Effects
- ⚠sleep disruption
- ⚠headache
- ⚠jitteriness
Research Overview
5-Amino-1MQ
Studies in diet-induced obese mice showed significant reductions in body weight, white adipose tissue mass, and cholesterol levels without changes in food intake. Works by inhibiting NNMT enzyme to increase NAD+ and activate sirtuins.
Neuropeptide S
Animal studies suggest NPS can reduce anxiety-like behavior while altering wakefulness and alertness through the NPS receptor system. Human cognitive data are very limited, and it has no approved clinical indication.
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