Secretin vs Macimorelin
Head-to-head comparison of Secretin (Human Secretin) and Macimorelin (Macimorelin acetate (AEZS-130)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Secretin | Macimorelin |
|---|---|---|
| Category | Gastrointestinal | Growth Hormone |
| Full Name | Human Secretin | Macimorelin acetate (AEZS-130) |
| Molecular Weight | 3055.4 Da | N/A |
| Half-Life | 5-7 minutes | about 4-6 hours |
| Amino Acids | 27 | N/A |
| Typical Dose | 0.2 mcg/kg IV | 0.5 mg/kg single oral dose |
| Route | Intravenous | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 800 | 120 |
| Research Status | Clinical | Clinical |
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
Macimorelin Benefits
- ✓diagnostic GH stimulation
- ✓single oral dose
- ✓rapid measurable GH response
- ✓high clinical utility
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
Macimorelin Dosing
0.5 mg/kg orally as a single dose|fasted testing conditions|serial GH sampling after administration
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
Macimorelin Side Effects
- ⚠dysgeusia or taste disturbance
- ⚠nausea
- ⚠headache
Research Overview
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
Macimorelin
Macimorelin has been validated in clinical testing as an oral alternative to injectable GH stimulation tests. Its short-term use makes it a useful translational tool for evaluating pituitary GH reserve.
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