Orexin-A vs Secretin
Head-to-head comparison of Orexin-A (Hypocretin-1 (Orexin-A)) and Secretin (Human Secretin) — benefits, dosing, side effects, research data, and where to buy.
| Property | Orexin-A | Secretin |
|---|---|---|
| Category | Cognitive Enhancement | Gastrointestinal |
| Full Name | Hypocretin-1 (Orexin-A) | Human Secretin |
| Molecular Weight | 3562 Da | 3055.4 Da |
| Half-Life | Minutes to <1 hour | 5-7 minutes |
| Amino Acids | 33 | 27 |
| Typical Dose | Research-only; no validated human dose | 0.2 mcg/kg IV |
| Route | Intracerebroventricular/Intranasal | Intravenous |
| Purity | ≥98% | ≥98% |
| Studies Count | 42 | 800 |
| Research Status | Pre-clinical | Clinical |
Orexin-A Benefits
- ✓wakefulness
- ✓attention
- ✓memory consolidation
- ✓fatigue resistance
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
Orexin-A Dosing
Research-only i.c.v. microgram/nanomolar studies|intranasal experimental use|no established human protocol
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
Orexin-A Side Effects
- ⚠insomnia
- ⚠headache
- ⚠blood pressure changes
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
Research Overview
Orexin-A
Preclinical studies link orexin signaling to arousal, learning, and memory consolidation, making orexin-A a candidate for cognition-related research. It is not an approved cognitive enhancer and remains an experimental peptide.
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
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