Omentin-1 vs NPY
Head-to-head comparison of Omentin-1 (Omentin-1 (Intelectin-1, ITLN1)) and NPY (Neuropeptide Y) — benefits, dosing, side effects, research data, and where to buy.
| Property | Omentin-1 | NPY |
|---|---|---|
| Category | Diabetes & Metabolic | Cognitive Enhancement |
| Full Name | Omentin-1 (Intelectin-1, ITLN1) | Neuropeptide Y |
| Molecular Weight | ~35 kDa | 4272 Da |
| Half-Life | hours | minutes |
| Amino Acids | 313 | 36 aa |
| Typical Dose | No approved human dose; research use only | 1-10 µg preclinical range |
| Route | IV|SC | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 82 | 900 |
| Research Status | Pre-clinical | Pre-clinical |
Omentin-1 Benefits
- ✓insulin sensitivity
- ✓glucose uptake
- ✓lipid handling
NPY Benefits
- ✓stress resilience
- ✓hippocampal protection
- ✓memory modulation
- ✓anti-excitotoxic signaling
Omentin-1 Dosing
not established|not established
NPY Dosing
0.1-1 nmol ICV in rodents|1-10 µg intranasal in experimental work|acute or repeated stress-model protocols
Omentin-1 Side Effects
- ⚠unknown
- ⚠immunogenicity risk
NPY Side Effects
- ⚠sedation
- ⚠appetite increase
- ⚠blood pressure changes
Research Overview
Omentin-1
Lower omentin-1 levels are often associated with obesity, insulin resistance, and metabolic syndrome. Research continues on its use as a biomarker and as a mechanistic lead for AMPK-linked metabolic interventions.
NPY
NPY has been shown in animal studies to protect neurons from excitotoxic injury and to dampen stress-linked cognitive impairment. It is often discussed as a counterbalance to overactive glutamatergic and stress pathways in the brain.
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