Omentin-1 vs GPE
Head-to-head comparison of Omentin-1 (Omentin-1 (Intelectin-1, ITLN1)) and GPE (Glycyl-L-prolyl-L-glutamic acid) — benefits, dosing, side effects, research data, and where to buy.
| Property | Omentin-1 | GPE |
|---|---|---|
| Category | Diabetes & Metabolic | Cognitive Enhancement |
| Full Name | Omentin-1 (Intelectin-1, ITLN1) | Glycyl-L-prolyl-L-glutamic acid |
| Molecular Weight | ~35 kDa | 301.30 Da |
| Half-Life | hours | minutes |
| Amino Acids | 313 | 3 |
| Typical Dose | No approved human dose; research use only | 0.1-10 mg/kg preclinical |
| Route | IV|SC | Intranasal/Intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 82 | 25 |
| Research Status | Pre-clinical | Pre-clinical |
Omentin-1 Benefits
- ✓insulin sensitivity
- ✓glucose uptake
- ✓lipid handling
GPE Benefits
- ✓memory consolidation
- ✓neuroprotection
- ✓synaptic plasticity
- ✓learning support
Omentin-1 Dosing
not established|not established
GPE Dosing
intranasal or ICV research doses|0.1-10 mg/kg preclinical range|repeat daily or intermittent protocols
Omentin-1 Side Effects
- ⚠unknown
- ⚠immunogenicity risk
GPE Side Effects
- ⚠limited human safety data
- ⚠short half-life
- ⚠local irritation with nasal delivery
Research Overview
Omentin-1
Lower omentin-1 levels are often associated with obesity, insulin resistance, and metabolic syndrome. Research continues on its use as a biomarker and as a mechanistic lead for AMPK-linked metabolic interventions.
GPE
Preclinical studies suggest GPE can reduce neuronal damage and support plasticity-related pathways in the brain. Research interest centers on hippocampal function, which links it to learning and memory paradigms.
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