Noopept vs NPY
Head-to-head comparison of Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) and NPY (Neuropeptide Y) — benefits, dosing, side effects, research data, and where to buy.
| Property | Noopept | NPY |
|---|---|---|
| Category | Cognitive Enhancement | Cognitive Enhancement |
| Full Name | N-phenylacetyl-L-prolylglycine ethyl ester | Neuropeptide Y |
| Molecular Weight | 318.37 Da | 4272 Da |
| Half-Life | 20-30 minutes | minutes |
| Amino Acids | N/A | 36 aa |
| Typical Dose | 10-30 mg/day | 1-10 µg preclinical range |
| Route | Oral | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 60 | 900 |
| Research Status | Clinical | Pre-clinical |
Noopept Benefits
- ✓memory recall
- ✓learning efficiency
- ✓attention support
- ✓neurotrophic signaling
NPY Benefits
- ✓stress resilience
- ✓hippocampal protection
- ✓memory modulation
- ✓anti-excitotoxic signaling
Noopept Dosing
oral research use|10-30 mg per day in human studies|divided or single daily dosing
NPY Dosing
0.1-1 nmol ICV in rodents|1-10 µg intranasal in experimental work|acute or repeated stress-model protocols
Noopept Side Effects
- ⚠headache
- ⚠irritability
- ⚠sleep disturbance
NPY Side Effects
- ⚠sedation
- ⚠appetite increase
- ⚠blood pressure changes
Research Overview
Noopept
Noopept has been reported to increase NGF/BDNF-related signaling and improve performance in tasks involving learning and recall. Evidence includes preclinical studies and small human studies, but the overall literature is still modest compared with mainstream cognitive drugs.
NPY
NPY has been shown in animal studies to protect neurons from excitotoxic injury and to dampen stress-linked cognitive impairment. It is often discussed as a counterbalance to overactive glutamatergic and stress pathways in the brain.
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