Neuropeptide S vs Oxyntomodulin
Head-to-head comparison of Neuropeptide S (Neuropeptide S) and Oxyntomodulin (Endogenous glucagon-like peptide 1 and glucagon co-agonist peptide) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Neuropeptide S | Oxyntomodulin |
|---|---|---|
| Category | Cognitive Enhancement | Weight Management |
| Full Name | Neuropeptide S | Endogenous glucagon-like peptide 1 and glucagon co-agonist peptide |
| Molecular Weight | 2203 Da | ~4,200 Da |
| Half-Life | Minutes to <1 hour | 12-15 minutes |
| Amino Acids | 20 | 37 |
| Typical Dose | Research-only; no validated human dose | Research doses vary; commonly 100-300 mcg in small human studies |
| Route | Intracerebroventricular/Intranasal | Subcutaneous/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 28 | 80 |
| Research Status | Pre-clinical | Clinical |
Neuropeptide S Benefits
- ✓anxiolysis
- ✓stress resilience
- ✓attention support
- ✓arousal modulation
Oxyntomodulin Benefits
- ✓reduces appetite
- ✓increases satiety
- ✓supports weight loss
- ✓improves postprandial metabolic signaling
Neuropeptide S Dosing
0.1-1 nmol i.c.v. in animal studies|intranasal research-only exploration|no established human protocol
Oxyntomodulin Dosing
Research-only dosing|Subcutaneous or IV administration in trials|Pair with calorie restriction and monitoring
Neuropeptide S Side Effects
- ⚠sleep disruption
- ⚠headache
- ⚠jitteriness
Oxyntomodulin Side Effects
- ⚠nausea
- ⚠GI discomfort
- ⚠decreased appetite beyond target
Research Overview
Neuropeptide S
Animal studies suggest NPS can reduce anxiety-like behavior while altering wakefulness and alertness through the NPS receptor system. Human cognitive data are very limited, and it has no approved clinical indication.
Oxyntomodulin
Human studies showed acute reductions in food intake and modest weight loss, helping establish the GLP-1 and glucagon co-agonism concept. It remains a foundational peptide for obesity and satiety research.
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