MK-677 vs CJC-1295
Head-to-head comparison of MK-677 (Ibutamoren Mesylate (MK-677)) and CJC-1295 (Growth Hormone Releasing Hormone Analog) — benefits, dosing, side effects, research data, and where to buy.
| Property | MK-677 | CJC-1295 |
|---|---|---|
| Category | Growth Hormone | Performance |
| Full Name | Ibutamoren Mesylate (MK-677) | Growth Hormone Releasing Hormone Analog |
| Molecular Weight | 528.662 g/mol | 3,367.97 Da |
| Half-Life | ~24 hours | ~6-8 days (DAC) |
| Amino Acids | Non-peptide compound | 30 |
| Typical Dose | — | 1-2 mg/week |
| Route | — | SC |
| Purity | >99% | — |
| Studies Count | 120 | 167 |
| Research Status | Active Research | Clinical Trials |
MK-677 Benefits
- ✓Oral GH secretagogue, 24-hour GH elevation, increases IGF-1, improves sleep quality, increases lean mass, does not suppress natural GH
CJC-1295 Benefits
- ✓Sustained GH release over days
- ✓Improved body composition
- ✓Enhanced deep sleep quality
- ✓Accelerated recovery from training
- ✓Increased protein synthesis
MK-677 Dosing
10-25 mg orally once daily before bedtime. 25 mg is the most studied dose. Can be used long-term without cycling.
CJC-1295 Dosing
Without DAC: 100-200 mcg SC 2-3 times daily|With DAC: 1-2 mg SC once or twice weekly|Combined with Ipamorelin: 100 mcg each, 2-3x daily
MK-677 Side Effects
- ⚠Increased appetite, mild water retention, drowsiness, transient numbness, mild increase in fasting blood glucose with long-term use.
CJC-1295 Side Effects
- ⚠Common (Mild): Water retention, tingling/numbness, flushing
- ⚠Moderate: Joint stiffness, carpal tunnel-like symptoms
- ⚠Rare: Elevated blood sugar (transient)
Research Overview
MK-677
A landmark 2-year study in elderly adults demonstrated significant increases in lean mass, GH pulsatility, and IGF-1 to youthful ranges. Selectively agonizes GHS-R1a without increasing cortisol or prolactin.
CJC-1295
CJC-1295 has good pre-clinical and early clinical data. The DAC variant shows sustained GH elevation for days. Often combined with GHRPs for synergistic GH release.
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