Meldonium vs ACE-031
Head-to-head comparison of Meldonium (3-(2,2,2-Trimethylhydrazinium)propionate) and ACE-031 (ACE-031 (soluble activin receptor type IIB-Fc)) — benefits, dosing, side effects, research data, and where to buy.
| Property | Meldonium | ACE-031 |
|---|---|---|
| Category | Muscle & Performance | Muscle & Performance |
| Full Name | 3-(2,2,2-Trimethylhydrazinium)propionate | ACE-031 (soluble activin receptor type IIB-Fc) |
| Molecular Weight | 146.19 Da | ~95 kDa |
| Half-Life | ~3-6 h | Days to weeks |
| Amino Acids | N/A | N/A |
| Typical Dose | 500-1000 mg/day in divided oral doses | 0.1-3 mg/kg in early studies |
| Route | Oral/IV | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 70 | 75 |
| Research Status | Clinical | Clinical |
Meldonium Benefits
- ✓improves exercise tolerance
- ✓may reduce ischemic fatigue
- ✓supports metabolic efficiency
- ✓may aid recovery
ACE-031 Benefits
- ✓myostatin/activin neutralization
- ✓lean mass gain
- ✓muscle function support
- ✓anti-catabolic effect
Meldonium Dosing
500 mg orally daily|500 mg orally twice daily|500-1000 mg/day in divided doses
ACE-031 Dosing
Clinical studies used single or repeated SC doses|dose escalation in mg/kg|monitoring for edema/bleeding
Meldonium Side Effects
- ⚠GI upset
- ⚠headache
- ⚠palpitations
ACE-031 Side Effects
- ⚠telangiectasia/vascular effects
- ⚠epistaxis
- ⚠headache/edema
Research Overview
Meldonium
Clinical literature focuses on cardiometabolic support and exercise tolerance rather than direct anabolic effects. Any endurance benefit is thought to come from altered substrate handling and improved tolerance to stress.
ACE-031
ACE-031 produced increases in lean mass in early studies, but development was curtailed after safety concerns and variable efficacy. Its literature remains important because it validated activin receptor blockade as a muscle-building strategy.
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