Histatin-5 vs NGF
Head-to-head comparison of Histatin-5 (Human histatin 5) and NGF (Beta-Nerve Growth Factor (human NGF beta)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Histatin-5 | NGF |
|---|---|---|
| Category | Dental & Oral | Cognitive Enhancement |
| Full Name | Human histatin 5 | Beta-Nerve Growth Factor (human NGF beta) |
| Molecular Weight | 3035 Da | 13,600 Da |
| Half-Life | minutes in saliva | hours |
| Amino Acids | 24 | 118 aa |
| Typical Dose | 1-100 µM in research formulations | research-only microgram range |
| Route | Topical/Oral rinse | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 120 | 3500 |
| Research Status | Pre-clinical | Pre-clinical |
Histatin-5 Benefits
- ✓anti-Candida activity
- ✓biofilm suppression
- ✓mucosal wound support
- ✓oral innate immunity
NGF Benefits
- ✓neurite outgrowth
- ✓cholinergic support
- ✓nerve repair
- ✓neuroprotection
Histatin-5 Dosing
topical rinse or gel|short contact exposure|repeat applications in research protocols
NGF Dosing
0.01-1 µg/kg in experimental delivery studies|local CNS or intranasal research delivery|single or repeated low-dose protocols
Histatin-5 Side Effects
- ⚠local irritation
- ⚠proteolytic instability
- ⚠dose-dependent cytotoxicity in vitro
NGF Side Effects
- ⚠pain at injection site
- ⚠hyperalgesia
- ⚠autonomic effects
Research Overview
Histatin-5
Histatin-5 is a major salivary defense peptide that can kill Candida species and influence oral microbial communities. It is also investigated for wound-healing and xerostomia-associated oral infection models.
NGF
NGF is one of the most established growth factors in neurobiology and has been investigated for both central and peripheral neuronal repair. Its strongest cognitive relevance comes from supporting basal forebrain cholinergic neurons and downstream memory circuitry.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.