HGH Fragment 176-191 vs Setmelanotide
Head-to-head comparison of HGH Fragment 176-191 (Human Growth Hormone Fragment 176-191) and Setmelanotide (Setmelanotide Acetate) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | HGH Fragment 176-191 | Setmelanotide |
|---|---|---|
| Category | Weight Management | Weight Management |
| Full Name | Human Growth Hormone Fragment 176-191 | Setmelanotide Acetate |
| Molecular Weight | 1817.12 g/mol | N/A |
| Half-Life | ~30 minutes | Approximately 11-16 hours |
| Amino Acids | 16 | N/A |
| Typical Dose | — | 1-3 mg daily |
| Route | — | Subcutaneous |
| Purity | >98% | ≥98% |
| Studies Count | 45 | 80 |
| Research Status | Active Research | Clinical |
HGH Fragment 176-191 Benefits
- ✓Targeted fat loss, no blood sugar impact, no IGF-1 elevation, inhibits lipogenesis, stimulates lipolysis, improved body composition
Setmelanotide Benefits
- ✓reduced hyperphagia
- ✓body-weight reduction
- ✓MC4R pathway activation
- ✓improved satiety signaling
HGH Fragment 176-191 Dosing
250-500 mcg subcutaneously 1-2 times daily on empty stomach. 12-16 week cycles typical in research.
Setmelanotide Dosing
1 mg SC daily|titrate weekly to 2-3 mg/day|follow study or label-based escalation
HGH Fragment 176-191 Side Effects
- ⚠Injection site irritation, headache, drowsiness. Does not affect blood sugar, insulin sensitivity, or elevate IGF-1.
Setmelanotide Side Effects
- ⚠hyperpigmentation
- ⚠nausea
- ⚠injection-site reactions
- ⚠fatigue
Research Overview
HGH Fragment 176-191
This 16-amino-acid fragment specifically targets adipose tissue via beta-3 adrenergic receptors. Works through a GH-receptor-independent pathway, explaining selective fat-loss properties without growth-promoting effects.
Setmelanotide
Setmelanotide has shown clinically meaningful reductions in hunger and weight in POMC, PCSK1, and LEPR-related obesity. It is one of the most important mechanistic peptides for rare-disease obesity research.
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