HGH Fragment 176-191 vs Cotadutide
Head-to-head comparison of HGH Fragment 176-191 (Human Growth Hormone Fragment 176-191) and Cotadutide (MEDI0382, long-acting GLP-1 and glucagon receptor dual agonist) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | HGH Fragment 176-191 | Cotadutide |
|---|---|---|
| Category | Weight Management | Weight Management |
| Full Name | Human Growth Hormone Fragment 176-191 | MEDI0382, long-acting GLP-1 and glucagon receptor dual agonist |
| Molecular Weight | 1817.12 g/mol | ~4,700 Da |
| Half-Life | ~30 minutes | Approximately 24 hours |
| Amino Acids | 16 | 37 |
| Typical Dose | — | 0.3-3 mg daily in clinical studies |
| Route | — | Subcutaneous |
| Purity | >98% | ≥98% |
| Studies Count | 45 | 18 |
| Research Status | Active Research | Clinical |
HGH Fragment 176-191 Benefits
- ✓Targeted fat loss, no blood sugar impact, no IGF-1 elevation, inhibits lipogenesis, stimulates lipolysis, improved body composition
Cotadutide Benefits
- ✓body-weight reduction
- ✓improved insulin sensitivity
- ✓reduced hepatic fat
- ✓appetite suppression
HGH Fragment 176-191 Dosing
250-500 mcg subcutaneously 1-2 times daily on empty stomach. 12-16 week cycles typical in research.
Cotadutide Dosing
Once-daily SC in trials|Start low and titrate based on tolerance|Monitor GI adverse effects
HGH Fragment 176-191 Side Effects
- ⚠Injection site irritation, headache, drowsiness. Does not affect blood sugar, insulin sensitivity, or elevate IGF-1.
Cotadutide Side Effects
- ⚠nausea
- ⚠vomiting
- ⚠diarrhea
Research Overview
HGH Fragment 176-191
This 16-amino-acid fragment specifically targets adipose tissue via beta-3 adrenergic receptors. Works through a GH-receptor-independent pathway, explaining selective fat-loss properties without growth-promoting effects.
Cotadutide
Phase 2 studies reported dose-dependent weight loss and favorable changes in glycemic and liver-related markers. It is one of the most cited synthetic dual-agonist peptides for obesity research.
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