HGH Fragment 176-191 vs Macimorelin
Head-to-head comparison of HGH Fragment 176-191 (Human Growth Hormone Fragment 176-191) and Macimorelin (Macimorelin acetate (AEZS-130)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | HGH Fragment 176-191 | Macimorelin |
|---|---|---|
| Category | Weight Management | Growth Hormone |
| Full Name | Human Growth Hormone Fragment 176-191 | Macimorelin acetate (AEZS-130) |
| Molecular Weight | 1817.12 g/mol | N/A |
| Half-Life | ~30 minutes | about 4-6 hours |
| Amino Acids | 16 | N/A |
| Typical Dose | — | 0.5 mg/kg single oral dose |
| Route | — | Oral |
| Purity | >98% | ≥98% |
| Studies Count | 45 | 120 |
| Research Status | Active Research | Clinical |
HGH Fragment 176-191 Benefits
- ✓Targeted fat loss, no blood sugar impact, no IGF-1 elevation, inhibits lipogenesis, stimulates lipolysis, improved body composition
Macimorelin Benefits
- ✓diagnostic GH stimulation
- ✓single oral dose
- ✓rapid measurable GH response
- ✓high clinical utility
HGH Fragment 176-191 Dosing
250-500 mcg subcutaneously 1-2 times daily on empty stomach. 12-16 week cycles typical in research.
Macimorelin Dosing
0.5 mg/kg orally as a single dose|fasted testing conditions|serial GH sampling after administration
HGH Fragment 176-191 Side Effects
- ⚠Injection site irritation, headache, drowsiness. Does not affect blood sugar, insulin sensitivity, or elevate IGF-1.
Macimorelin Side Effects
- ⚠dysgeusia or taste disturbance
- ⚠nausea
- ⚠headache
Research Overview
HGH Fragment 176-191
This 16-amino-acid fragment specifically targets adipose tissue via beta-3 adrenergic receptors. Works through a GH-receptor-independent pathway, explaining selective fat-loss properties without growth-promoting effects.
Macimorelin
Macimorelin has been validated in clinical testing as an oral alternative to injectable GH stimulation tests. Its short-term use makes it a useful translational tool for evaluating pituitary GH reserve.
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