HGH Fragment 176-191 vs Elamipretide
Head-to-head comparison of HGH Fragment 176-191 (Human Growth Hormone Fragment 176-191) and Elamipretide (Elamipretide (MTP-131, SS-31)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | HGH Fragment 176-191 | Elamipretide |
|---|---|---|
| Category | Weight Management | Muscle & Performance |
| Full Name | Human Growth Hormone Fragment 176-191 | Elamipretide (MTP-131, SS-31) |
| Molecular Weight | 1817.12 g/mol | 639.8 Da |
| Half-Life | ~30 minutes | 1-4 hours |
| Amino Acids | 16 | 4 |
| Typical Dose | — | 0.01-0.25 mg/kg/day |
| Route | — | Subcutaneous/Intravenous |
| Purity | >98% | ≥98% |
| Studies Count | 45 | 120 |
| Research Status | Active Research | Clinical |
HGH Fragment 176-191 Benefits
- ✓Targeted fat loss, no blood sugar impact, no IGF-1 elevation, inhibits lipogenesis, stimulates lipolysis, improved body composition
Elamipretide Benefits
- ✓mitochondrial protection
- ✓reduced oxidative stress
- ✓improved fatigue resistance
- ✓may support exercise tolerance
HGH Fragment 176-191 Dosing
250-500 mcg subcutaneously 1-2 times daily on empty stomach. 12-16 week cycles typical in research.
Elamipretide Dosing
0.01-0.25 mg/kg/day SC (clinical research)|daily dosing in trials|alternative IV protocols in some studies
HGH Fragment 176-191 Side Effects
- ⚠Injection site irritation, headache, drowsiness. Does not affect blood sugar, insulin sensitivity, or elevate IGF-1.
Elamipretide Side Effects
- ⚠nausea
- ⚠injection-site reactions
- ⚠diarrhea
- ⚠headache
Research Overview
HGH Fragment 176-191
This 16-amino-acid fragment specifically targets adipose tissue via beta-3 adrenergic receptors. Works through a GH-receptor-independent pathway, explaining selective fat-loss properties without growth-promoting effects.
Elamipretide
Clinical and translational studies show elamipretide can improve mitochondrial function and some functional endpoints in mitochondrial disorders. Skeletal muscle research suggests benefits are driven by energy metabolism rather than direct muscle-building effects.
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