Elamipretide vs IGF-1 LR3
Head-to-head comparison of Elamipretide (Elamipretide (MTP-131, SS-31)) and IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Elamipretide | IGF-1 LR3 |
|---|---|---|
| Category | Muscle & Performance | Performance |
| Full Name | Elamipretide (MTP-131, SS-31) | Insulin-like Growth Factor-1 Long R3 |
| Molecular Weight | 639.8 Da | 9,117 Da |
| Half-Life | 1-4 hours | ~20-30 hours |
| Amino Acids | 4 | 83 |
| Typical Dose | 0.01-0.25 mg/kg/day | 20-100 mcg |
| Route | Subcutaneous/Intravenous | IM / SC |
| Purity | ≥98% | — |
| Studies Count | 120 | 298 |
| Research Status | Clinical | Pre-clinical |
Elamipretide Benefits
- ✓mitochondrial protection
- ✓reduced oxidative stress
- ✓improved fatigue resistance
- ✓may support exercise tolerance
IGF-1 LR3 Benefits
- ✓Promotes muscle hyperplasia (new muscle cells)
- ✓Extended half-life vs native IGF-1
- ✓Enhanced protein synthesis
- ✓Improved nutrient partitioning
- ✓Anti-catabolic effects
Elamipretide Dosing
0.01-0.25 mg/kg/day SC (clinical research)|daily dosing in trials|alternative IV protocols in some studies
IGF-1 LR3 Dosing
Standard: 20-50 mcg IM post-workout|Advanced: 50-100 mcg IM or SC daily|Cycle: 4-6 weeks on, 4 weeks off
Elamipretide Side Effects
- ⚠nausea
- ⚠injection-site reactions
- ⚠diarrhea
- ⚠headache
IGF-1 LR3 Side Effects
- ⚠Common: Hypoglycemia (dose-dependent), joint pain, water retention
- ⚠Moderate: Gut growth concern (high doses), acromegaly-like symptoms
- ⚠Serious: Theoretical cancer risk (prolonged high-dose use)
Research Overview
Elamipretide
Clinical and translational studies show elamipretide can improve mitochondrial function and some functional endpoints in mitochondrial disorders. Skeletal muscle research suggests benefits are driven by energy metabolism rather than direct muscle-building effects.
IGF-1 LR3
IGF-1 LR3 has extensive in vitro and animal data. Its role in muscle hyperplasia is well-documented. The extended half-life modification provides practical advantages over native IGF-1.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.