Dulaglutide vs Oxyntomodulin
Head-to-head comparison of Dulaglutide (Recombinant GLP-1 receptor agonist Fc fusion protein) and Oxyntomodulin (Endogenous glucagon-like peptide 1 and glucagon co-agonist peptide) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Dulaglutide | Oxyntomodulin |
|---|---|---|
| Category | Weight Management | Weight Management |
| Full Name | Recombinant GLP-1 receptor agonist Fc fusion protein | Endogenous glucagon-like peptide 1 and glucagon co-agonist peptide |
| Molecular Weight | ~63,000 Da | ~4,200 Da |
| Half-Life | About 5 days | 12-15 minutes |
| Amino Acids | N/A | 37 |
| Typical Dose | 0.75-4.5 mg weekly | Research doses vary; commonly 100-300 mcg in small human studies |
| Route | Subcutaneous | Subcutaneous/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 700 | 80 |
| Research Status | Approved | Clinical |
Dulaglutide Benefits
- ✓modest weight loss
- ✓lower A1c
- ✓weekly dosing convenience
- ✓cardiometabolic benefit
Oxyntomodulin Benefits
- ✓reduces appetite
- ✓increases satiety
- ✓supports weight loss
- ✓improves postprandial metabolic signaling
Dulaglutide Dosing
0.75-4.5 mg SC weekly|Increase based on response and tolerance|Administer on the same day each week
Oxyntomodulin Dosing
Research-only dosing|Subcutaneous or IV administration in trials|Pair with calorie restriction and monitoring
Dulaglutide Side Effects
- ⚠nausea
- ⚠diarrhea
- ⚠injection-site reactions
Oxyntomodulin Side Effects
- ⚠nausea
- ⚠GI discomfort
- ⚠decreased appetite beyond target
Research Overview
Dulaglutide
Dulaglutide has repeatedly shown small-to-moderate reductions in body weight alongside glycemic improvement in large diabetes trials. It is a useful comparator for GLP-1 receptor agonist effects on appetite and weight.
Oxyntomodulin
Human studies showed acute reductions in food intake and modest weight loss, helping establish the GLP-1 and glucagon co-agonism concept. It remains a foundational peptide for obesity and satiety research.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.