Cotadutide vs Oxyntomodulin
Head-to-head comparison of Cotadutide (MEDI0382, long-acting GLP-1 and glucagon receptor dual agonist) and Oxyntomodulin (Endogenous glucagon-like peptide 1 and glucagon co-agonist peptide) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cotadutide | Oxyntomodulin |
|---|---|---|
| Category | Weight Management | Weight Management |
| Full Name | MEDI0382, long-acting GLP-1 and glucagon receptor dual agonist | Endogenous glucagon-like peptide 1 and glucagon co-agonist peptide |
| Molecular Weight | ~4,700 Da | ~4,200 Da |
| Half-Life | Approximately 24 hours | 12-15 minutes |
| Amino Acids | 37 | 37 |
| Typical Dose | 0.3-3 mg daily in clinical studies | Research doses vary; commonly 100-300 mcg in small human studies |
| Route | Subcutaneous | Subcutaneous/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 18 | 80 |
| Research Status | Clinical | Clinical |
Cotadutide Benefits
- ✓body-weight reduction
- ✓improved insulin sensitivity
- ✓reduced hepatic fat
- ✓appetite suppression
Oxyntomodulin Benefits
- ✓reduces appetite
- ✓increases satiety
- ✓supports weight loss
- ✓improves postprandial metabolic signaling
Cotadutide Dosing
Once-daily SC in trials|Start low and titrate based on tolerance|Monitor GI adverse effects
Oxyntomodulin Dosing
Research-only dosing|Subcutaneous or IV administration in trials|Pair with calorie restriction and monitoring
Cotadutide Side Effects
- ⚠nausea
- ⚠vomiting
- ⚠diarrhea
Oxyntomodulin Side Effects
- ⚠nausea
- ⚠GI discomfort
- ⚠decreased appetite beyond target
Research Overview
Cotadutide
Phase 2 studies reported dose-dependent weight loss and favorable changes in glycemic and liver-related markers. It is one of the most cited synthetic dual-agonist peptides for obesity research.
Oxyntomodulin
Human studies showed acute reductions in food intake and modest weight loss, helping establish the GLP-1 and glucagon co-agonism concept. It remains a foundational peptide for obesity and satiety research.
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