Cholecystokinin-8 vs Omentin-1
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and Omentin-1 (Omentin-1 (Intelectin-1, ITLN1)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | Omentin-1 |
|---|---|---|
| Category | Endocrine Peptides | Diabetes & Metabolic |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Omentin-1 (Intelectin-1, ITLN1) |
| Molecular Weight | 1143.2 Da | ~35 kDa |
| Half-Life | 1-2 min | hours |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 313 |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | No approved human dose; research use only |
| Route | endogenous secretion|research IV/SC | IV|SC |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 82 |
| Research Status | Endogenous | Pre-clinical |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
Omentin-1 Benefits
- ✓insulin sensitivity
- ✓glucose uptake
- ✓lipid handling
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
Omentin-1 Dosing
not established|not established
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Omentin-1 Side Effects
- ⚠unknown
- ⚠immunogenicity risk
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
Omentin-1
Lower omentin-1 levels are often associated with obesity, insulin resistance, and metabolic syndrome. Research continues on its use as a biomarker and as a mechanistic lead for AMPK-linked metabolic interventions.
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