C-peptide vs NPY
Head-to-head comparison of C-peptide (Connecting peptide (C-peptide)) and NPY (Neuropeptide Y) — benefits, dosing, side effects, research data, and where to buy.
| Property | C-peptide | NPY |
|---|---|---|
| Category | Pain Management | Cognitive Enhancement |
| Full Name | Connecting peptide (C-peptide) | Neuropeptide Y |
| Molecular Weight | 3020.3 Da | 4272 Da |
| Half-Life | ~20-30 min | minutes |
| Amino Acids | 31 | 36 aa |
| Typical Dose | no approved analgesic dose|research-only | 1-10 µg preclinical range |
| Route | IV|subQ | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 46 | 900 |
| Research Status | Pre-clinical | Pre-clinical |
C-peptide Benefits
- ✓diabetic neuropathy research
- ✓nerve function support
- ✓possible analgesic effect
NPY Benefits
- ✓stress resilience
- ✓hippocampal protection
- ✓memory modulation
- ✓anti-excitotoxic signaling
C-peptide Dosing
0.5-1.0 mg/day in research|route varies by protocol
NPY Dosing
0.1-1 nmol ICV in rodents|1-10 µg intranasal in experimental work|acute or repeated stress-model protocols
C-peptide Side Effects
- ⚠injection-site reactions
- ⚠unknown long-term safety
NPY Side Effects
- ⚠sedation
- ⚠appetite increase
- ⚠blood pressure changes
Research Overview
C-peptide
C-peptide is not an approved analgesic, but multiple studies have examined its effects on peripheral nerve blood flow and neuropathy outcomes. The strongest relevance is in diabetic neuropathic pain rather than migraine.
NPY
NPY has been shown in animal studies to protect neurons from excitotoxic injury and to dampen stress-linked cognitive impairment. It is often discussed as a counterbalance to overactive glutamatergic and stress pathways in the brain.
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