Bremelanotide vs NPY
Head-to-head comparison of Bremelanotide (Bremelanotide (PT-141), cyclic melanocortin receptor agonist) and NPY (Neuropeptide Y) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Bremelanotide | NPY |
|---|---|---|
| Category | Sexual Health | Cognitive Enhancement |
| Full Name | Bremelanotide (PT-141), cyclic melanocortin receptor agonist | Neuropeptide Y |
| Molecular Weight | 1025.2 Da | 4272 Da |
| Half-Life | about 2.7 h | minutes |
| Amino Acids | 7 | 36 aa |
| Typical Dose | 1.75 mg | 1-10 µg preclinical range |
| Route | Subcutaneous | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 200 | 900 |
| Research Status | Clinical | Pre-clinical |
Bremelanotide Benefits
- ✓increases sexual desire
- ✓supports arousal
- ✓may improve erectile response
- ✓on-demand use
NPY Benefits
- ✓stress resilience
- ✓hippocampal protection
- ✓memory modulation
- ✓anti-excitotoxic signaling
Bremelanotide Dosing
1.75 mg subcutaneous PRN|administer about 45 minutes before activity|max 1 dose per 24 hours
NPY Dosing
0.1-1 nmol ICV in rodents|1-10 µg intranasal in experimental work|acute or repeated stress-model protocols
Bremelanotide Side Effects
- ⚠nausea
- ⚠flushing
- ⚠headache
- ⚠transient blood pressure increase
NPY Side Effects
- ⚠sedation
- ⚠appetite increase
- ⚠blood pressure changes
Research Overview
Bremelanotide
Human studies and approval data support meaningful effects on sexual desire in women, with a central mechanism involving melanocortin signaling. It is one of the most clinically relevant peptides in this category and is commonly used as the reference compound for PT-141-type research.
NPY
NPY has been shown in animal studies to protect neurons from excitotoxic injury and to dampen stress-linked cognitive impairment. It is often discussed as a counterbalance to overactive glutamatergic and stress pathways in the brain.
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