Anamorelin vs Ibutamoren
Head-to-head comparison of Anamorelin (Anamorelin hydrochloride (ONO-7643)) and Ibutamoren (Ibutamoren mesylate (MK-677)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Anamorelin | Ibutamoren |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | Anamorelin hydrochloride (ONO-7643) | Ibutamoren mesylate (MK-677) |
| Molecular Weight | N/A | N/A |
| Half-Life | about 9 hours | about 24 hours |
| Amino Acids | N/A | N/A |
| Typical Dose | 50 mg/day | 10-25 mg/day |
| Route | Oral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 95 | 180 |
| Research Status | Clinical | Clinical |
Anamorelin Benefits
- ✓stimulates appetite
- ✓raises IGF-1
- ✓may support weight gain
- ✓oral dosing
Ibutamoren Benefits
- ✓raises GH/IGF-1
- ✓increases appetite
- ✓supports lean mass retention
- ✓oral non-peptide secretagogue
Anamorelin Dosing
50 mg orally once daily|often studied with food or per protocol|track weight, appetite, and glucose markers
Ibutamoren Dosing
10-25 mg orally once daily|take consistently at the same time each day|monitor fasting glucose and edema in longer studies
Anamorelin Side Effects
- ⚠hyperglycemia
- ⚠peripheral edema
- ⚠constipation or nausea
Ibutamoren Side Effects
- ⚠increased appetite
- ⚠water retention/edema
- ⚠somnolence or lethargy
Research Overview
Anamorelin
Trials in cachexia populations showed increased appetite and modest gains in body weight and IGF-1. Regulatory progress has varied by region, but it remains a well-studied ghrelin agonist in the GH space.
Ibutamoren
Clinical studies show oral ibutamoren reliably elevates GH and IGF-1 over 24 hours with once-daily dosing. Body composition and appetite effects vary by population, and development has been limited by metabolic side effects.
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