AICAR vs Histatin-5
Head-to-head comparison of AICAR (5-Aminoimidazole-4-carboxamide Ribonucleotide (Acadesine)) and Histatin-5 (Human histatin 5) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | AICAR | Histatin-5 |
|---|---|---|
| Category | Performance | Dental & Oral |
| Full Name | 5-Aminoimidazole-4-carboxamide Ribonucleotide (Acadesine) | Human histatin 5 |
| Molecular Weight | 338.21 g/mol | 3035 Da |
| Half-Life | ~2-3 hours | minutes in saliva |
| Amino Acids | Nucleoside analog | 24 |
| Typical Dose | — | 1-100 µM in research formulations |
| Route | — | Topical/Oral rinse |
| Purity | >99% | ≥98% |
| Studies Count | 180 | 120 |
| Research Status | Active Research | Pre-clinical |
AICAR Benefits
- ✓Increases endurance capacity, enhances fatty acid oxidation, promotes mitochondrial biogenesis, improves glucose uptake, cardioprotective effects
Histatin-5 Benefits
- ✓anti-Candida activity
- ✓biofilm suppression
- ✓mucosal wound support
- ✓oral innate immunity
AICAR Dosing
Research doses: 50-150 mg subcutaneously. Typically administered 30-60 minutes before physical activity in research settings.
Histatin-5 Dosing
topical rinse or gel|short contact exposure|repeat applications in research protocols
AICAR Side Effects
- ⚠Potential hypoglycemia, lactic acidosis at high doses, injection site reactions. Banned by WADA as a metabolic modulator.
Histatin-5 Side Effects
- ⚠local irritation
- ⚠proteolytic instability
- ⚠dose-dependent cytotoxicity in vitro
Research Overview
AICAR
Salk Institute researchers demonstrated AICAR could increase endurance in sedentary mice by 44% without exercise training. Activates AMPK, triggering PGC-1α expression, mitochondrial biogenesis, and enhanced fatty acid β-oxidation.
Histatin-5
Histatin-5 is a major salivary defense peptide that can kill Candida species and influence oral microbial communities. It is also investigated for wound-healing and xerostomia-associated oral infection models.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.