AICAR vs Arenicin-1
Head-to-head comparison of AICAR (5-Aminoimidazole-4-carboxamide Ribonucleotide (Acadesine)) and Arenicin-1 (Arenicin-1) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | AICAR | Arenicin-1 |
|---|---|---|
| Category | Performance | Marine-Derived |
| Full Name | 5-Aminoimidazole-4-carboxamide Ribonucleotide (Acadesine) | Arenicin-1 |
| Molecular Weight | 338.21 g/mol | 2079 Da |
| Half-Life | ~2-3 hours | n/a |
| Amino Acids | Nucleoside analog | 21 |
| Typical Dose | — | n/a |
| Route | — | preclinical |
| Purity | >99% | ≥98% |
| Studies Count | 180 | 76 |
| Research Status | Active Research | Pre-clinical |
AICAR Benefits
- ✓Increases endurance capacity, enhances fatty acid oxidation, promotes mitochondrial biogenesis, improves glucose uptake, cardioprotective effects
Arenicin-1 Benefits
- ✓antimicrobial
- ✓anti-biofilm
- ✓membrane-active
AICAR Dosing
Research doses: 50-150 mg subcutaneously. Typically administered 30-60 minutes before physical activity in research settings.
Arenicin-1 Dosing
bacterial infection|biofilm disruption
AICAR Side Effects
- ⚠Potential hypoglycemia, lactic acidosis at high doses, injection site reactions. Banned by WADA as a metabolic modulator.
Arenicin-1 Side Effects
- ⚠Arenicola marina
Research Overview
AICAR
Salk Institute researchers demonstrated AICAR could increase endurance in sedentary mice by 44% without exercise training. Activates AMPK, triggering PGC-1α expression, mitochondrial biogenesis, and enhanced fatty acid β-oxidation.
Arenicin-1
Marine annelid peptide with strong preclinical antibacterial activity and a stable structural motif that is useful for peptide engineering.
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